Abstract
Follicular lymphoma is the second most frequent type of non-Hodgkin's lymphoma in adults. The basic molecular defect consists of the t(14;18)(q32;q21) translocation, juxtaposing the B-cell lymphoma protein 2 gene BCL2 to the immunoglobulin heavy chain locus IGH@, and leading to the antiapoptotic BCL2 protein overproduction. Variations in the t(14;18) are rare and can be classified into two categories: (i) simple variants, involving chromosomes 18 and 2, or 22, in which the fusion partner of BCL2 is the light-chain IGK@ or IGL@; (ii) complex variant translocations occurring among chromosomes 14, 18 and other chromosomes. We report a follicular lymphoma case showing BCL2 overexpression, detected by immunohistochemistry and real-time quantitative PCR, consequently to the formation of a novel fusion gene between the 5′ of the lymphoid nuclear transcriptional activator gene AFF3 at 2q11.2, and the 3′ of BCL2. This case shows evidence, for the first time, of BCL2 overexpression consequently to the fusion of BCL2 to a non-IG partner locus.
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Acknowledgements
We thank Dr Maria Corsignano Guastadisegni for her contribution to the study, and Professor Roscoe Stanyon for language revision of an earlier version. This study has been supported by the AIRC (Associazione Italiana per la Ricerca sul Cancro), and the MiUR (Ministero dell’Istruzione, dell’Università e della Ricerca).
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Impera, L., Albano, F., Lo Cunsolo, C. et al. A novel fusion 5′AFF3/3′BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma. Oncogene 27, 6187–6190 (2008). https://doi.org/10.1038/onc.2008.214
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DOI: https://doi.org/10.1038/onc.2008.214
