Table 1 The effects of knocking out murine equivalents of 5q genes
Mouse phenotype | Drf1 | Egr1 | Apc | Npm1 |
|---|---|---|---|---|
Elevated WBC | + | + | − | + |
Lymphopenia | + | − | + | − |
Monocytosis | + | + | − | + |
Granulocytosis | + | + | − | + |
Anemia | + | + | + | + |
Thrombocytosis | + | − | − | − |
Thrombocytopenia | − | + | + | + |
Splenomegaly | + | + | − | + |
Hepatomegaly | − | − | − | + |
Extramedullary hematopoiesis | + | + | − | + |
Loss of splenic organization | + | + | − | + |
Myeloproliferative defects | + | + | − | + |
Ineffective erythropoiesis in | ||||
Bone marrow | + | + | + | + |
Spleen | + | + | + | + |
