Figure 6
From: Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin
Menin regulates FAK and ERK1/2 activation through PTN/RPTP β/ζ and represses cell migration partly through ERK1/2. (a) Serum-starved A549 cells were treated with 100 ng/ml recombinant human PTN (rhPTN) and harvested at various time points. The activation of FAK and ERK1/2 were determined with western blotting. (b) A549 cells were transfected with PTN or RPTP β/ζ shRNA, pFAK and pERK1/2 were examined with western blotting. (c) Migration of A549 cells treated with LY294002 or U0126 were significantly reduced in a dose-dependent manner. N=3, *P<0.05. (d) A model for regulation of cell migration by menin through growth factor PTN/RPTP β/ζ.
