Figure 2 | Oncogene

Figure 2

From: SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis

Figure 2

Promoter methylation of SPG20 is associated with loss of gene expression. (a) Gene expression and DNA promoter methylation status of SPG20 in cell lines. The quantitative gene expression levels are shown as ratios between the median of SPG20 and the average of two endogenous controls, GUSB and ACTB. (b) Relative gene expression of SPG20 in colon cancer cell lines treated with 1 μM AZA for 72 h, 0.5 μM TSA for 12 h and a combination of both drugs (AZA+TSA). AZA, 5-aza-2′deoxycytidine; SPG20, spastic paraplegia-20; TSA, trichostatin-A.

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