Table 1 Frequency and distribution of promoter methylation levels (PMR values) in normal colorectal mucosas, adenomas and carcinomas as measured by qMSP

From: SPG20, a novel biomarker for early detection of colorectal cancer, encodes a regulator of cytokinesis

SPG20

Normal mucosas

Adenomas

Carcinomas

P-valuea

 

n (%)

Median (IQR)

n (%)

Median (IQR)

n (%)

Median (IQR)

 

Test set

1/51 (2%)

0.49 (1.18)

45/60 (75%)

20.17 (33.13)

67/74 (91%)

44.77 (47.15)

5.32E-21

Validation set

0/59 (0%)

1.88 (2.13)

42/51 (82%)

29.25 (47.08)

92/105 (88%)

37.29 (35.41)

9.27E-24

Combined (test and validation)

1/110 (1%)

1.17 (2.36)

87/111 (78%)

23.97 (33.85)

159/179 (89%)

39.21 (39.84)

1.33E-42

  1. Abbreviations: IQR, interquartile range (75th percentile–25th percentile); n, number of positive cases; PMR, percentage methylated reference; qMSP, quantitative methylation-specific PCR; SPG20, spastic paraplegia-20.
  2. aKruskal–Wallis test.
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