Figure 4
CDDP differentially increases the intracellular Ca2+ concentration [Ca2+]i in OVCA cells. (a) CDDP induced [Ca2+]i increase in OV2008, but not C13* cells. The effect of CDDP on [Ca2+]i was assessed by confocal microscopy. CPA induced (b) [Ca2+]i increase, (c) calpain activation, TAp73α and ΔNp73α downregulation/cleavage and apoptosis in both OV2008 and C13* cells. Images and figures present the mean±s.e.m. of three independent experiments (*P<0.05, **P<0.01, ***P<0.001).
