Figure 1
From: FZD7 has a critical role in cell proliferation in triple negative breast cancer
Microarray-based detection of overexpressed Wnt pathway genes in TNBC. (a) Gene ontology analysis (GOTERM_BP_ALL) was performed using the DAVID online tool, Functional Annotation Clustering identified a significantly upregulated cluster of genes in TNBC (P<0.01). (b) Pathway analysis (KEGG_PATHWAY) using the DAVID online tool identified the Wnt pathway as being significantly active in TNBA (P<0.05). (c) Summary of microarray results indicating that LRP6, FDZ7 and TCF7 were significantly upregulated in TNBC (>1.5 fold, P<0.01). (d) Normalized intensity of each FZD for each tumor sample, as obtained from microarray. The average intensity of each FZD in TNBC and non-TNBC is shown. Ratio of TNBC vs non-TNBC was plotted.
