Figure 6
From: FZD7 has a critical role in cell proliferation in triple negative breast cancer
FZD7 knockdown suppressed tumor growth in vivo. (a) Tumor size was measured twice per week for 3 weeks. Graph shows mean tumor volume of eight mice; bar: s.d. (upper panel). Multiple comparison test with Tukey adjustment was used to compare the difference, ***P<0.001. All tumors were harvested and photographed (lower panel); (b) immunohistochemical staining, with antibodies against the indicated proteins of MDA-MD-231 tumors with or without FZD7 knockdown. (c) RT–PCR analysis to detect expression of the canonical Wnt pathway target genes Axin2, Cyclin D1 and Myc in FZD7+ (GFPshRNA) and FZD7-/low (FZD7shRNA) tumors.
