Figure 7
From: PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein
A model of the effect of PAX8 regulation on RB and E2F1 expression. PAX8 positively regulates both RB and E2F1 expression through different mechanisms. PAX8 binds to the E2F1 promoter, thereby transcriptionally activating E2F1 expression. In comparison, interaction of PAX8 with RB stabilizes the RB protein, which then forms a negative feedback loop, restricting PAX8-mediated E2F1 expression. We propose that this PAX8-mediated E2F1 regulation could be essential to maintain cell proliferation signal before S-phase entry. RB, retinoblastoma.
