Table 2 Inhibition of endogenous β-catenin-response genes in cancer cell lines

From: Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer

Cell line

Origin

Wnt pathway activated by:

Axin2 (% of control)

β-Catenin (% of control)

c-Myc (% of control)

SW480

Colon cancer

APC

24±13

134±5

ND

HCT116

Colon cancer

β-Catenin mutation

24±9

ND

35±13

DLD-1

Colon cancer

APC

43±4

205±6

59±11

HT29

Colon cancer

APC

97±9

173±9

38±11

STF3A

Neuroendocrine (HEK293)

High WNT3A

122±10

173±6

ND

MDA-MB-231

Breast cancer

None

103±16

74±12

ND

HT1080

Fibrosarcoma

None

142±8

ND

150±3

  1. Abbreviations: APC, adenomatous polyposis coli; ND, assay not done.
  2. Cells were treated overnight with 10 μM N-((8-hydroxy-7-quinolinyl) (4-methylphenyl)methyl)benzamide, and then indicated gene expression was assessed by reverse transcriptase–quantitative PCR.
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