Figure 2
From: Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma
Hipk2-deficient mice are susceptible to radiation-induced tumor development. (a) Spontaneous and radiation-induced tumorigenesis in Hipk2+/− and wild-type mice. 37 Hipk2+/− and 31 wild-type mice were exposed to a single dose of a 4-Gy γ-irradiation at 5 weeks of age. At the same time, 51 Hipk2+/− and 34 wild-type mice acted as unirradiated controls. (b) Radiation-induced tumorigenesis in double heterozygous Hipk2+/−p53+/− (n=36) and p53+/− (n=29) mice, showing the cooperative effects of partial deficiency in both genes.
