Figure 2 | Oncogene

Figure 2

From: Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate

Figure 2

Gene Ontology analysis of enriched and depleted processes and networks in CAFs vs NPFs. GeneGo software was used to compare transcripts identified in CAF with NPF. CAF-enriched processes were predominantly those involved in prostate development, but also included those involved in other reproductive organ growth such as uterus, oocyte and vagina. The processes most depleted in CAFs were associated with cell cycle, suggesting a lower proliferative rate in CAFs. Gene Ontology analysis was also applied to molecules enriched or depleted in CAFs and co-expressed in CD90+ve stromal cells and reactive stroma (Supplementary File 3). The top networks enriched in CAFs included ASPN, FBLN1, FN and OGN.

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