Figure 4 | Oncogene

Figure 4

From: Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate

Figure 4

Distribution of identified candidate proteins in fetal human prostate. Samples are orientated with the posterior at the top and the anterior at the bottom, UR denotes urethra, SV denotes seminal vesicles, and selected prostatic ducts are highlighted with arrows in (a, b). The scale bar represents 500 μm. (a–m) Low-magnification images: expression of ASPN, FBLN, PARVA, ZEB1, CAV1, CFH, NKTR and STC1 was observed in a subset of prostatic mesenchyme; and ASPN, FBLN, PARVA, CAV1 and NKTR showed enrichment in prostatic mesenchyme at the periphery of the organ where epithelial branching morphogenesis is concentrated. Expression of CTSK and S100A6 was highly restricted to a small subset of cells in the mesenchyme, while OGN was broadly expressed throughout the mesenchyme. (n–y) High-magnification images: mesenchyme-specific staining for CTSK, FBLN, FN, OGN, PARVA, CAV1, S100A6 and STC1. There was some evidence of nuclear staining in epithelia for ASPN, while ZEB1, CFH, NKTR and STC1 showed limited expression in a subset of epithelia. Scale bar is 50 μm, E, epithelia; M, mesenchyme.

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