Figure 3
From: GILZ inhibits the mTORC2/AKT pathway in BCR-ABL+ cells
GILZ increases Bim expression in BCR-ABL+ cells. (a) WB analysis of Bcl-2 family members in GILZ- and Void-M1 and Void-DA1 cells. (b) Real-time PCR analysis of Bim expression in M1-GILZ cells relative to M1-Void cells. **P<0.01, Kruskal–Wallis test. (c) K562-r cells transfected with human GILZ were analyzed as described in panel a. (d) WB analysis of Bcl-2 family members in GILZ- and Void-M1 and Void-DA1 cells exposed for 12 h to imatinib. The graphs represent mean±s.d. of three separate experiments performed in triplicate.
