Figure 8
From: GILZ inhibits the mTORC2/AKT pathway in BCR-ABL+ cells
Summary of GILZ's regulatory effects on the AKT pathway in BCR-ABL cells. (a) BCR-ABL activates AKT through PI3K and mTORC2. Phosphorylation of AKT at Ser473 inhibits Bim expression and apoptosis through Foxo3A. (b) GILZ interacts with mTORC2 and reduces AKT (Ser473) phosphorylation, leading to Bim expression and apoptosis.
