Figure 3
From: DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer
Aberrant DNA methylation patterns in human cancer. Heavily methylated repetitive sequences undergo hypomethylation events in transformed cells that might cause genome instability (right panel), whereas unmethylated promoter CpG islands of coding genes and miRNAs with tumor-suppressor features become hypermethylated and silenced in cancer cells (left panel).
