Figure 5
Impaired integrin traffic induces aneuploidy and tumor formation also in vivo. (a) Mean tumor area (mm2) 0–7 weeks after injection. The tumor progression for each sample group during the whole experiment is shown (the growth curves of the β1wt sample groups are not visible) (mean±s.e.m., n=10; **P<0.005, ***P<0.0005). (b) Hematoxylin and eosin (HE) staining of sarcomas from mice injected with β1YYFF_L0a or β1YYFF_L4a cells, scale bar 100 μm. (c) Quantification of chromosome numbers of tumor cell lines from β1YYFF_L4a mice (n=9–13 cells per group). All cell lines are aneuploid. (d) Karyotype of a β1YYFF_L4a-derived tumor cell line shows structural and numerical aberrations. Six metaphases were analyzed. (e) Quantification of chromosome numbers of tumor cell lines from β1YYFF_L0a mice (n=39–51 cells per group). All cell lines are aneuploid.
