Figure 8 | Oncogene

Figure 8

From: MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways

Figure 8

miR-520c is inversely correlated with lymph node metastasis in ER− breast cancer. (a) Expression of miR-520c in ER− primary tumors with (n=6) or without (n=15) lymph node metastasis (LN-positive or -negative). Vertical line represents the median. Data were analyzed using one-tailed unpaired t-test (*P=0.0221). (b) The same samples as in (a) were analyzed for TGFBR2 expression levels (one-tailed unpaired t-test, ***P=0.0003). (c) Model of the molecular mechanisms by which miR-520/373 regulate breast cancer cell invasion, metastasis and transcriptional regulation of metastasis-promoting genes.

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