Table 1 Expression and localization of EGFR, IL-6, and PAI-1 in formalin-fixed, paraffin embedded EOC samples evaluated by IHC

From: Ligand-dependent EGFR activation induces the co-expression of IL-6 and PAI-1 via the NFkB pathway in advanced-stage epithelial ovarian cancer

EOC sample a

EGFR

IL-6

PAI-1

 

M

C

C

C

1

 

+/++b

−

+

2

++

 

+

+

3

+

 

+

+

4

++

 

+

++

5

+

++

+

++

6

++

++

+

+

7

+++

+++

+++

+++

8

++

 

++

+

9

 

+

−

−

10

+

+

+

+

11

 

++

++

++

12

++

 

+

++

13

 

++

−

+

14

++

++

−

−

15

++

+

+

+

16

 

+/++

−

+

17

+++

 

−

−

18

 

+++

+

++

19

+++

 

−

++

20

+++

+++

+

++

21

++

+++

+

++

22

+++

+++

+++

+++

23

+

+

+

+

  1. Abbreviations: C, cytoplasmic staining; EGFR, epidermal growth factor receptor; EOC, epithelial ovarian cancer; IHC, immunohistochemistry; M, membrane staining, PAI, plasminogen activator inhibitor.
  2. aThe characteristics of EOC patients are reported in Supplementary Table 1. The numbers in bold italics highlight patients whose ascites co-expressed detectable levels of IL-6 and PAI-1 (see Figure 6b).
  3. bArbitrary scores were given by two independent observers: negative (−), faint (+), moderate (++), and strong (+++) staining.