Figure 1 | Oncogene

Figure 1

From: Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

Figure 1

Distribution of somatic APC mutations by amino acid for 630 sporadic CRCs. (a) Frequencies of protein-truncating and missense mutations are shown above and below the x axis, respectively. (b) Cumulative frequency of truncating mutations; the somatic mutation cluster region (codons 1282–1581) is highlighted. APC protein domains and exon structure are indicated.

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