Figure 3 | Oncogene

Figure 3

From: Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis

Figure 3

Distribution of truncating APC mutations upstream of the somatic MCR according to number of intact 20AARs left by the MCR hit for CRCs with two mutations, one within the MCR and one 5′ to the MCR (n=130). Cancers with 2–3 intact 20AARs show an overrepresentation of 5′ non-MCR mutations downstream of codon 767 leaving an intact armadillo-repeat domain, whereas cancers with 1 intact 20AAR show an overrepresentation of 5′ non-MCR mutations upstream of codon 768 disrupting or removing the armadillo-repeat domain. Cases with 3 intact 20AARs are shown in green, 2 intact 20AARs in blue, and 1 intact 20AAR in red.

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