Table 1 Clinicopathological characteristics of 630 patients with sporadic CRC according to the number of somatic APC hits (truncating mutation and LOH)
Characteristic | All patients | Number of APC hits | P-value | |||||
|---|---|---|---|---|---|---|---|---|
0 Hits (%) | 1 Hit (%) | 2 Hits (%) | 3 Hits (%) | Any hit (%) | 0 vs any hit | 3 vs 1 or 2 hits | ||
Age, years | ||||||||
Median | 70 | 73 | 69 | 69 | 73 | 69 | 0.002* | 0.147 |
Range | 30–99 | 31–99 | 30–93 | 33–92 | 50–86 | 30–93 | ||
Gender | ||||||||
Male | 353 (56.0) | 70 (19.8) | 83 (23.5) | 195 (55.2) | 5 (1.4) | 283 (80.2) | <0.001* | 0.011* |
Female | 277 (44.0) | 89 (32.1) | 53 (19.1) | 123 (44.4) | 12 (4.3) | 188 (67.9) | ||
Location | ||||||||
Proximal colon | 273 (43.3) | 93 (34.1) | 48 (17.6) | 118 (43.2) | 14 (5.1) | 180 (65.9) | <0.001* | 0.001* |
Distal colon | 198 (31.4) | 34 (17.2) | 47 (23.7) | 115 (58.1) | 2 (1.0) | 164 (82.8) | ||
Rectum | 159 (25.2) | 32 (20.1) | 41 (25.8) | 85 (53.5) | 1 (0.6) | 127 (79.9) | ||
Tumour stage | ||||||||
I | 60 (9.5) | 12 (20.0) | 11 (18.3) | 36 (60.0) | 1 (1.7) | 48 (80.0) | 0.200 | 0.406 |
II | 188 (29.8) | 44 (23.4) | 37 (19.7) | 100 (53.2) | 7 (3.7) | 144 (76.6) | ||
III | 296 (47.0) | 86 (29.1) | 68 (23.0) | 137 (46.3) | 5 (1.7) | 210 (70.9) | ||
IV | 86 (13.7) | 17 (19.8) | 20 (23.3) | 45 (52.3) | 4 (4.7) | 69 (80.2) | ||
Differentiation | ||||||||
Well/moderate | 458 (76.0) | 97 (21.2) | 99 (21.6) | 249 (54.4) | 13 (2.8) | 361 (78.8) | 0.001* | 0.760 |
Poor | 145 (24.0) | 52 (35.9) | 28 (19.3) | 61 (42.1) | 4 (2.8) | 93 (64.1) | ||
Unknown | 27 | 10 | 9 | 8 | 0 | 17 | ||
Lymphovascular invasion | ||||||||
Absent | 215 (63.2) | 44 (20.5) | 36 (16.7) | 124 (57.7) | 11 (5.1) | 171 (79.5) | 0.890 | 0.583 |
Present | 125 (36.8) | 27 (21.6) | 25 (20.0) | 69 (55.2) | 4 (3.2) | 98 (78.4) | ||
Unknown | 290 | 88 | 75 | 125 | 2 | 202 | ||
Mucinous histology | ||||||||
No | 397 (79.1) | 80 (20.2) | 88 (22.2) | 217 (54.7) | 12 (3.0) | 317 (79.8) | 0.001* | 0.192 |
Yes | 105 (20.9) | 38 (36.2) | 16 (15.2) | 46 (43.8) | 5 (4.8) | 67 (63.8) | ||
Unknown | 128 | 41 | 32 | 55 | 0 | 87 | ||
MSI status | ||||||||
MSS | 540 (85.7) | 99 (18.3) | 127 (23.5) | 302 (55.9) | 12 (2.2) | 441 (81.7) | <0.001* | 0.003* |
MSI | 90 (14.3) | 60 (66.7) | 9 (10.0) | 16 (17.8) | 5 (5.6) | 30 (33.3) | ||
