Figure 2 | Oncogene

Figure 2

From: Imiquimod directly inhibits Hedgehog signalling by stimulating adenosine receptor/protein kinase A-mediated GLI phosphorylation

Figure 2

IMQ does not target the Tlr7/8–Myd88 signalling axis. (a) Relative mRNA expression levels of Tlr7, Tlr8 and Myd88 in two murine BCC cell lines. Data from murine splenocytes were set to 100%. (b and c) BSZ2 cells were treated either with control shRNA or an shRNA targeting Myd88 mRNA to investigate the possible effect of Myd88 on the IMQ-induced reduction of Gli1 expression. Cyclopamine (Cyc) is used as a control. Results shown are mean values and s.e.m. of three independent experiments.

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