Figure 9
From: p53-dependent gene repression through p21 is mediated by recruitment of E2F4 repression complexes
Global correlation between p53-mediated gene repression and E2F4 promoter occupancy. (a) Heatmap showing the correlation between the E2F4 ChIP-seq peak score and the p53 microarray expression levels. Row Z-score was performed on the log2-transformed values for each gene. (b) E2F4 ChIP-seq peak scores were divided into low (<4.5), medium (4.5–7.5), high (7.5–20), and very high (>20) binding groups. The percentage of p53 upregulated and downregulated genes, normalized for total gene number, that fall into each of these categories is shown in the form of a bar graph.
