Figure 3
RNF31 is highly expressed and is correlated to ERα target genes in tumour samples. (a) RNF31 is highly expressed in breast tumors. The expression of RNF31 was determined for 72 breast tumors and 37 adjacent breast tissues using qPCR. The Student’s t-test was used for comparison. Whiskers, 10th and 90th percentile; box boundaries, 75th and 25th percentile; line within box, median. Dots above the boxes show sample maximum values. asterisk (*) indicates outliers. (b) Correlation between expression of RNF31 and expression of the classical positively regulated ERα target genes GREB1 and pS2 (TFF1). Expression levels are derived from the TCGA mRNA database, test statistics from Pearson product-moment correlation. (c) Heat map showing correlation between RNF31 mRNA levels and mRNA levels of known ERα target genes. Included ERα target genes correspond to genes displaying significant correlation with RNF31 in Supplementary Table S2. RNA expression data are from the TCGA RNA-sequencing database.
