Table 1 Top 10 signaling pathways changed by RNF31 depletion in MCF-7 cells as determined by sub-network enrichment analysis

From: The atypical ubiquitin ligase RNF31 stabilizes estrogen receptor α and modulates estrogen-stimulated breast cancer cell proliferation

Node

Number of genes

P-value

TNF

119

6.01E−08

Sp1

95

3.49E−07

ERα

40

5.61E−07

IL-1β

79

6.80E−07

TGF-β1

100

6.36E−06

TIMP3

8

9.35E−06

EGF

58

1.43E−05

MAPK3

38

1.69E−05

GR

35

3.86E−05

SMAD7

15

5.33E−05

  1. Abbreviations: ERα, estrogen receptor α; EGF, epidermal growth factor; IL-1β, interleukin-1β; MAPK3, mitogen-activated protein kinase 3; TGF-β1, transforming growth factor-β1; TNF, tumor necrosis factor; IMP3, tissue inhibitor of metalloproteinases-3.
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