Figure 2

Non-cell-autonomous roles of cancer cell miRNAs in regulation of tumor microenvironment. Alteration of miR-9 (a), miR-126 (b), miR-135b (c), miR-29b (d), miR-30b/d (e), miR-34a (f) and miR-199a-5p/3p and miR-1908 (g) in cancer cells elicit distal impacts on tumor microenvironment to promote tumor progression through various non-cell-autonomous mechanisms. Oncogenic miRNAs and tumor-suppressive miRNAs are represented by black and red, respectively.