Figure 1 | Oncogene

Figure 1

From: MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes

Figure 1

miR-206 is downregulated in tumor versus normal pancreatic tissue. (a) Heatmap visualization of differentially expressed miRNAs in 7 normal vs 25 tumor tissues of early PDAC patients (GSE32688 data set). Differential expression of miRNAs between tumor and normal samples was assessed using bioconductor’s limma R-package. miRNAs with P-value <0.01 (Benjamini–Hochberg corrected) were included into a heatmap visualization, using euclidean distance with the ward clustering method. (b) Expression of miR-206 in normal (n=7) and tumor (n=25) pancreatic tissues. Data represent log2 expression values. Vertical line represents the median (Whiskers: Tukey). Data were analyzed using two-tailed unpaired t-test (*P=0.018). (c) Expression levels of miR-206 in normal (n=2) and PDAC (n=6) cell lines as determined by qPCR. Data were analyzed using two-tailed unpaired t-test (*P=0.0417).

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