Figure 7 | Oncogene

Figure 7

From: MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genes

Figure 7

Schematic representation of the miR-206 proposed mode of action in modulating PDAC tumor responses. miR-206 functions as a tumor suppressor in PDAC cells by directly dampening the antiapoptotic KRAS-induced NF-κB pathway activity, thus leading to transcriptional inhibition of the expression of multiple pro-angiogenic, pro-lymphangiogenic and growth factors, thus limiting endothelial (EC) and lymphatic endothelial cell activation and tumor growth. In addition, miR-206 inhibits ECM remodeling by directly targeting ANXA2, which serves as a proteolytic center for ECM degradation.

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