Figure 4 | Oncogene

Figure 4

From: c-MYC is a radiosensitive locus in human breast cells

Figure 4

FISH analysis of c-MYC copy number and chromosome 8 copy number in sporadic and radiogenic breast cancers. c-MYC copy number was assessed in tumour cells from radiogenic cancers (n=9) and from sporadic cancers (n=20). c-MYC copy number was higher in the radiogenic cancers (Mann–Whitney U-test; P=0.027) (a). The wider horizontal bars represent the median c-MYC copy number and the narrower horizontal bars represent the 10th and 90th percentiles of the data. The percentage of samples in which at least 10% of the nuclei contained ⩾3, 4, 5 and 6 copies of c-MYC was compared (b) and was significantly higher in the radiogenic cohort than in the sporadic cohort for ⩾6 copies of c-MYC (Fisher's exact test; P=0.022 (*)). The ratio between c-MYC and chromosome 8 centromere copy number was higher in the radiogenic cohort than in the sporadic cohort (Mann–Whitney U-test; P=0.016) (c). The percentage of samples in each cohort, which had a c-MYC to chromosome 8 centromere ratio ⩽1.10 (no or little evidence of c-MYC amplification) or >1.10 (evidence of c-MYC amplification) was also compared (d) (Fisher's exact test; P=0.010).

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