Figure 2 | Oncogene

Figure 2

From: Development of secondary mutations in wild-type and mutant EZH2 alleles cooperates to confer resistance to EZH2 inhibitors

Figure 2

K-R2 and K-R10 cells showed resistance to multiple EZH2 inhibitors. (a) H3K27Me0, Me1, Me2, and Me3 were quantitated by mass spectrometry in K-P cells treated with 10 μM EI1 or EPZ-6438. (b) Growth inhibition by EI1 and EPZ-6438 in a 6-day proliferation assay. Y-axis shows percent of growth normalized to DMSO controls. (c, d) Growth inhibition by EI1 (c) and EPZ-6438 (d). (e) DMSO-treated samples are normalized to 100% BrdU incorporation (Y-axis) and percent of BrdU incorporation (average from two independent experiments) are indicated.

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