Figure 1 | Oncogene

Figure 1

From: Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish

Figure 1

Targeted disruption of zebrafish mdm2 and mdm4 using ZFNs. (a) A schematic representation of the genomic loci of zebrafish mdm2 on chromosome 4 and mdm4 on chromosome 11. The red arrow indicates the zinc-finger-binding and -cut site. Various known protein domains are indicated in different colors: cyan, Mdm2/SWIB (p53-binding domain); yellow, RanBP2-type zinc-finger; fuschia, RING finger. (b) Alignments of partial coding sequences isolated from heterozygous F1 zebrafish carrying mdm2 mutant alleles. (c) Alignments of partial coding sequences isolated from heterozygous F1 zebrafish carrying mdm4 mutant alleles.

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