Figure 3 | Oncogene

Figure 3

From: Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish

Figure 3

Rescue of mdm2−/− embryos with microinjection of FLAG-mdm2 mRNA. Single-cell embryos collected from an incross of mdm2+/− fish were injected with 25 or 50 pg of mRNA and imaged at ~30 hpf. (a) Wild type/mdm2+/− sibling embryo; (b) uninjected mdm2−/−embryo; (c) mdm2−/− embryo injected with 25 pg FLAG-mdm2 mRNA; (d) mdm2−/− embryo injected with 50 pg FLAG-mdm2 mRNA; (e) mdm2−/− embryo injected with 25 pg FLAG-mdm2C448A mRNA; and (f) mdm2−/− embryo injected with 50 pg FLAG-mdm2C448A mRNA.

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