Figure 1
From: Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response
Mutation signatures in MI tumor- and NMI tumor-derived bladder cell lines. (a) Mutation signatures in 21 MI tumor-derived lines. NGS variants (29 557 single-nucleotide variants (SNVs)) were grouped by the tri-nucleotide context. Arrows indicate motifs associated with altered CpGs (white) and APOBEC-family enzymes (black); arrow size indicates the relative contribution of specific motifs to variants observed in 238 MI primary tumors.24 (b) Motifs observed in 6472 SNVs in 4 NMI tumor-derived lines (MGH-U3, MGH-U4, RT4 and SW-780).
