Figure 3
From: Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response
Cell lines with altered signaling pathways and related protein functions. (a) PI3K/mTOR alterations in 15/25 (60%) cell lines. (b) BRCA pathway alterations in 11/25 (44%) cell lines. (c) Sister chromatid cohesion and segregation alterations in 6/25 (24%) cell lines. Variants are shown in an Oncoprint format (left) to identify genes that are co- or exclusively mutated; and as a pathway diagram (right) to show the frequency of altered protein components in each pathway. (d) SYNE1 and SYNE2 alterations in 15/25 (60%) cell lines. Colored boxes indicate protein domains: green, calponin homology domain; orange, spectrin repeat; blue, nuclear envelope localization domain. (e) MLL-family alterations in 12/25 (48% ) cell lines. Colored boxes indicate protein domains: green, PHD-like zinc-binding domain; orange, PHD-finger; blue, F/Y-rich N-terminus; yellow, F/Y-rich C-terminus; purple, SET domain. Variant annotation: green, missense; black, truncating (nonsense, deletion/insertion frameshift and splice junction).
