Figure 6

Deletion of chromosome 9p21.3 locus genes. (a) NGS of genes on chr 9 near CDKN2A and CDKN2B were manually examined using the IGV³⁴ for homozygous deletions. Lines with evidence of a homozygous deletion in an exon are displayed (green). The analysis was inconclusive for ELAVL2 exon 1 (right side) but no deletions were observed that extended to the neighboring gene, IZUMO family member 3. (b-d) The expression of the indicated chr 9 gene in lines with no homozygous deletion (left) as compared with lines with ⩾1 exon exhibiting a homozygous deletion (right). (b) MTAP expression in 18 WT lines and 7 lines with a deletion. (c) CDKN2A expression in 13 WT lines and 12 lines with a deletion. (d) CDKN2B expression in 16 WT lines and 9 lines with a deletion. Wilcoxon rank sum test was used to calculate P-values.