Figure 8
From: Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response
Pathway signature from cisplatin-treated cell lines predicts patient response. (a) Cell lines are ranked ordered according to measured response to cisplatin. Heatmap of PARADIGM scores for the top concepts from the elastic net analysis. The PARADIGM class is in parentheses and the fraction of times the concept was selected over 10 000 iterations of model training is shown in brackets. Concepts selected in over 80% of the iterations were used in the final model. (c) Patients from the TCGA were separated into two groups according to whether they received a platinum-based chemotherapy or not treated with chemotherapy. The cisplatin signature derived from the cell lines was used to predict sensitive and resistance in the two patient populations. Predictions were evaluated using a Kaplan–Meier survival plot (log-rank test).
