Figure 6
From: Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
E2F7-target genes are highly expressed in human SCC and are further increased by the deletion of E2f7 and E2f8. (a) Heatmap showing expression of E2F7 target genes in human cutaneous SCC and normal skin. (b) PANTHER gene ontology (GO) analysis of the 255 upregulated E2F7 target genes as shown in heatmap. Benjamini-adjusted log P-values were calculated using DAVID.49 (c) Expression of E2F family members and E2F target genes in human cutaneous SCC, determined by the Riker microarray data48 (normal skin n=4; SCC n=11). (d) Evaluation of transcript levels of E2F target genes in mouse SCC-1 samples (control n=6; 78Δ/Δ n=7; 78Δ/Δ1−/− n=8).
