Figure 1 | Oncogene

Figure 1

From: The Snail repressor recruits EZH2 to specific genomic sites through the enrollment of the lncRNA HOTAIR in epithelial-to-mesenchymal transition

Figure 1

HOTAIR expression correlates to mesenchymal genes. (a) RT–qPCR analysis for HOTAIR, EZH2, the indicated epithelial (E-cadherin and HNF4α) and mesenchymal (Snail, fibronectin and vimentin) genes on hepatocytes treated with TGFβ or not treated (NT) with TGFβ for 24 h. The values are calculated by the 2(−ΔCt) method, expressed as fold of expression versus the control (arbitrary value=1) and shown as means±s.e.m. Statistically significant differences are reported (*P<0.05, **P<0.01) for five independent experiments (NS=no significance). (b) RT–qPCR analysis for the same genes as in (a) in hepatocytes overexpressing HOTAIR (HOTAIR) or an empty vector (Ctr). The values are calculated by the 2(−ΔCt) method, expressed as fold of expression versus the control (arbitrary value=1) and shown as means±s.e.m. No statistically significant differences were evaluated for five independent experiments.

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