Figure 8 | Oncogene

Figure 8

From: Non-canonical NFκB mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB:p50 NFκB pathway

Figure 8

A schematic describing altered dynamic control of NFκB in diseased cells. A model depicting the proposed autoregulatory loop underlying protracted NFκB response to TNF in myeloma. Left, pro-inflammatory cytokines transiently induce NFκB activity, which is composed of RelA:p50 dimer, in healthy cells. Right, genetic aberrations in myeloma deplete p100 to provoke the autoregulatory circuitry in generating protracted RelB:p50/NF-κB response to canonical TNF signals.

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