Figure 7
Association of ‘activated-d16HER2 metagene’ levels with the NOTCH pathway in human HER2-positive BCs. (a, b) Notch pathway expression in human HER2-positive BCs of GSE55348(ref. 30) (a) and NKI data sets32 (b) according to the ‘activated-d16HER2 metagene’ classification. The data are shown as the mean of log2 expression of genes belonging to the Notch gene list (Supplementary Table S1). (c, d) Expression levels of Notch-downstream genes in human HER2-positive BCs of GSE55348 (c) or NKI (d) data sets with high or low expression of ‘activated-d16HER2 metagene’. Significance was calculated by a two-tailed unpaired t-test.
