Figure 1
From: RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma
Reduced expression of RBM47 is associated with poor outcomes for lung, breast and gastric cancer patients. (a) A scheme of RBM47 protein with interspecies amino acid conservation. RRM1–3, RNA recognition motifs 1–3. (b) The subcellular localization of endogenous RBM47 protein after treatment of H441 cells with 2.5 ng/ml TGF-β for 24 h was determined by immunoblotting. (c) The levels of RBM47 expression in a panel of 22 cell lines were examined using qRT–PCR and normalized with respect to GAPDH expression. (d) Survival rates based on RBM47 expression were analyzed by Kaplan–Meier survival method in lung (overall survival), breast (relapse-free survival) and gastric cancer (overall survival) patients. The half of patients with higher expression of RBM47 mRNA is indicated in red and that with lower expression is indicated in black. A log-rank test was used to compare the variance between the two groups.
