Figure 6
From: RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma
Mechanism of action of RBM47 through Nrf2 activity. RBM47 binds KEAP1 and CUL3 mRNAs to enhance their protein expression. RBM47 also transcriptionally (and indirectly) suppresses p21/CDKN1A and MafK expression both under unstimulated and TGF-β-stimulated conditions. CDKN1A suppression by RBM47 may result in enhanced KEAP1/CUL3-mediated inhibition of Nrf2.4, 5 Regulation of MafK expression may provide target and context dependency for the effects of both TGF-β and RBM47 on Nrf2 functions.21
