Figure 2 | Oncogene

Figure 2

From: The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage

Figure 2

p53 transcripts in p53+/+ and p53R172H/R172H mice testes. (a) p53 mRNA in situ hybridization by RNAscope technique in p53+/+, p53R172H/R172H and p53−/− mice testes. Inset boxes show magnified view of individual spermatogonium expressing p53 mRNA. Scale bar=20 μm. (b) β-galactosidase activity in spermatogonia of adult βGeo homozygous and heterozygous p53 promoter report mice. X-Gal staining was used to determine the βGeo expression patterns in mouse testis. Inset box shows p53+/+ negative control. Scale bar=100 μm.

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