Figure 7
1G6-D7 blocks tumour formation and metastasis in vivo. Although 1G6-D7 inhibits tumour cell invasion in vitro (see Supplementary Figure S6), it also works in vivo. (A) A representative experiment showing tumour formation of injected native MDA-MB-231 cells (5 × 106) in mice (n=3 or 5 per group) that were intravenously administered with either control mouse IgG or 1G6-D7 (5 mg/kg/injection) (Methods). (B) Measurement of tumour volumes on live mice over 4 weeks. (C) H&E staining of the primary tumour/tissue (panels a and c) or the lungs (panels b and d) sections from IgG control- or 1G6-D7-treated mice as indicated. T, tumour; N, normal tissue. 5/5, five out of five mice per group. This experiment was repeated three times (n=4 or 5 mice per group). Data are represented as mean±s.e.m. P<0.05.
