Figure 1

FOXP3 protein expression in PDAC cells and the clinical outcomes. (a) Immunohistochemical profiles (hematoxylin staining) of FOXP3 in normal pancreas, serous cystadenoma, pancreatic intraepithelial neoplasia (PanIN), pancreatic neuroendocrine tumor (PNET), spleen and PDAC tissues under microscopy. Magnification: × 200. (b) Expression of FOXP3 in normal pancreas cells (N) and PDAC (T) cells (brown). Magnification: × 40 and × 200. (c, d) Kaplan–Meier OS and RFS of PDAC patients, presented as high-c-FOXP3 or low-c-FOXP3 expression groups based on the log-rank statistic test (n=76 and n=44, respectively). Final scores of c-FOXP3 expression (1–9)=intensity score (1–3) × percentage score (1–3). High-c-FOXP3 >4 and low-c-FOXP3 ⩽4.