Figure 4
From: ER stress protein AGR2 precedes and is involved in the regulation of pancreatic cancer initiation
Downregulation of UPR proteins expression during PDAC initiation. (a) Immunohistochemical analysis of XBP1s, ATF6 and GRP78 proteins in human chronic pancreatitis. Scale bars, 50 μm. (b) Schematic representation of the UPR switch during formation of pancreatic pre-neoplastic lesions. TC, tubular complexes; PanIN, pancreatic intraepithelial neoplasia.
