Figure 1 | Oncogene

Figure 1

From: Ras oncogene-independent activation of RALB signaling is a targetable mechanism of escape from NRAS(V12) oncogene addiction in acute myeloid leukemia

Figure 1

Spontaneous relapse after suppression of Ras oncogene expression in mice with NRAS(V12)-driven AML. White blood cell (WBC) counts of leukemic SCID beige mice with NRAS(V12)-dependent (NRD) AML rapidly decline after doxycycline (Dox)-mediated suppression of NRAS(V12) expression. Two of five mice spontaneously relapsed with NRI AML (NRI1 and NRI1 AMLs) despite continued Dox treatment.

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