Figure 1 | Oncogene

Figure 1

From: Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality

Figure 1

Transcriptional signature of the adaptive tumor response to ATTs. (a) Genes differentially expressed following castration of host mice versus non-castrated (‘intact’) LNCaP tumor xenografts at PSA nadir and CR. NRP1 is indicated by the large blue dot in the upper right quadrant. (b) Numbers of genes common to three data sets: LNCaP Enz-upregulated genes (top left), genes upregulated in LNCaP xenografts post-castration (top right) and genes upregulated in mCRPC versus localized PCa (Grasso et al., bottom;11 GSE35988). (c) Heatmap showing differential expression of the 120 gene subset identified in b in metastatic versus localized PCa data sets.11, 12, 13, 14, 15 (d) NRP1 mRNA levels in clinical samples of metastasis versus primary localized PCa across multiple data sets.11, 12, 13, 14, 15 *P<0.05, ***P<0.001. In c and d, log2 median centered gene expression data was downloaded from the Oncomine database.

Back to article page