Figure 5
Schematic model for the chemokine-mediated micro-environmental translational regulation of MCL-1. Chemokines secreted directly by Mϕs or in an autocrine fashion by CLL cells after CD40 stimulation lead to triggering of the CCR1 receptor. This triggering induces AKT signaling and subsequent induction of mTOR-dependent 4E-BP phosphorylation and release of its inhibited binding partner eIF4E. Concurrently, the induction of ERK signaling by CD40 stimulation results in the phosphorylation of eIF4E. These processes facilitate the recruitment of eIF4E to the 5′ mRNA cap and formation of the ribosome, which results in the active translation of mRNA of pro-survival proteins like MCL-1.
